CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): In the oxyntic mucosa of the mammalian stomach, histamine is stored in ECL cells and in mucosal mast cells. In the rat, at least 80 percent of oxyntic mucosal histamine resides in the ECL cells. Histamine is a key factor in the regulation of gastric acid secretion.

Histamine is synthesized from histidine in ECL cells of the lamina propria (see Fig. 13-8B). In the second mechanism, ACh and gastrin indirectly induce acid

Histamine in the rat stomach resides in enterochromaffin-like (ECL) cells and mast cells. The ECL cells are peptide-hormone-producing endocrine cells known to release histamine and chromogranin-A-derived peptides (such as pancreastatin) in response to gastrin. In conclusion, gastrin is responsible for most of the food‐evoked mobilization of ECL‐cell histamine. The histamine response to electrical vagal stimulation reflects the effect of circulating gastrin rather than a direct action of the vagus on the ECL cells.

Aim: Gastrin stimulates acid secretion by mobilizing histamine from enterochromaffin‐like (ECL) cells that occur predominantly at the base of the gastric glands. The parietal cells occur higher up in the glands nearer to the gastric lumen. In terms of individual ECL cells and unit ECL cell volume, the serum pancreastatin concentration, the oxyntic mucosal histamine content, HDC activity, and HDC, CGA and CCK-B receptor mRNA contents Current students New students International Desk Academic matters & support IT services & support Careers Service Abstract. Histamine in the rat stomach resides in enterochromaffin-like (ECL) cells and mast cells. The ECL cells are peptide-hormone-producing endocrine cells known to release histamine and chromogranin-A-derived peptides (such as pancreastatin) in response to gastrin. In conclusion, gastrin is responsible for most of the food‐evoked mobilization of ECL‐cell histamine. The histamine response to electrical vagal stimulation reflects the effect of circulating gastrin rather than a direct action of the vagus on the ECL cells.

They produce HISTAMINE and peptides such as CHROMOGRANINS. ECL cells respond to The histamine-containing ECL cells constitute the most abundant endocrine cell type in the acid-producing part of the rat stomach; they constitute 0.5–1.0% of all 2013 — Histamine; Histamine receptors; Histamine H4 receptor, human; Atopic Histamin förmedlar sina cellfysiologiska verkningar via fyra G- Till professionella histaminproducerande celler räknas MC, basofiler, ECL celler och. av C Kampf · 2001 — induction of histamine release from mast cells and basophils (reviewed by chemiluminescence system (ECL-kit) (Amersham International) according to the.

“Enterochromaffin-like (ECL) cells” are a population of cells that are found in the gastric pits of the stomach luminal epithelium and secrete histamine. In response to gastrin released by neighbouring G-cells, secreted histamine from ECL cells acts on parietal cells to stimulate the release of gastric acid. What do chief cells secrete?

Gastrin itself is secreted by cells in the epithelium of the stomach, but travels to ECL cells via the blood. Together, histamine and gastrin are primary positive regulators of acid secretion from the parietal cell. Enterochromaffin-like (ECL) cells are neuroendocrine cells in the gastric mucosa that control acid secretion by releasing histamine as a paracrine stimulant.

”Open” cells: Spetsen på cellen har en öppning mot lumen och kan därför. känna av ECL-cell: innehåller enzymer som möjliggör produktion av histamin. 3.

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Highly purified (85%) ECL cells were collected from rat stomach using repeated counter 2016-01-25 Which of the following hormones stimulates the secretion of histamine from the ECL cells? a. Enterogastrone. b. Gastrin. c. Secretin.
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22 It is formed by the decarboxylation of histidine by histidine decarboxylase. ECL cell activation may be defined as the actions of regulatory factors that stimulate or inhibit histamine synthesis or secretion; the release of chromogranin A and its proteolytic product pancreastatin also are relevant, but histamine is the only product from the ECL cell that directly stimulates acid secretion by the parietal cell. HISTAMINE SECRETION FROM ECL CELLS Histamine secretion from ECL cells is of critical importance for gastric acid secretion. In vivo studies have shown that the antral hormone gastrin is the main stimulus for acid secretion and histamine release. This hormone is released from gastrin (G) cells of the antrum after food uptake and binds to Histamine stimulates the parietal cells to secrete HCl. The gastrin-ECL cell pathway has been investigated extensively in situ (gastric submucosal microdialysis), in vitro (isolated ECL cells) and in vivo (intact animals).

Histamine and the histamine-forming enzyme histidine decarboxylase (HDC) have been claimed to occur also in the gastrin-secreting G cells in the antrum.
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In response to gastrin released by neighbouring G-cells, secreted histamine from ECL cells acts on parietal cells to stimulate the release of gastric acid. Histamine is stored primarily in the ECL cells that reside in the basal half of the oxyntic gland.

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Histamine originates from enterochromaffin-like (ECL) cells, which are neuroendocrine cells located in the gastric mucosa. ECL cells secrete histamine when stimulated either by the autonomic nervous system or by gastrin. and mechanism of histamine release from the ECL cell in the peripheral regulation of acid secretion, usingpuri- fied ECL cells from rat fundic mucosa. Methods: Background & Aims: Gastrin stimulation of the type 2 cholecystokinin (CCK2) receptor results in ECL cell proliferation and histamine secretion. This report Abstract Enterochromaffin-like (ECL) cells are neuroendocrine cells in the gastric mucosa that control acid secretion by releasing histamine as a paracrine ECL cells respond to food intake or vagal nerve stimulation by releasing histamine (8), but the number of these cells is insignificant in the antral stomach. Finally, Feb 16, 2016 The gastrin (from G-cells) stimulates the ECL cells to produce and secrete histamine while, in a reciprocal way, this histamine (from ECL cells), The histamine-storing ECL cells in the stomach play a key role in the control of acid secretion.