Baseline cardiac troponin t levels are elevated in subjects with untreated diabetes mellitus: A cross-sectional study M Pareek, M L Nielsen, M Leósdóttir, P M Nilsson, M H Olsen KI, Endocrinology

25 Mar 2012 NT-proBNP and hsTnT levels were measured at baseline and after 2-3 years in older adults without HF in the Cardiovascular Health Study

None of the factors was helpful to differentiate MI and NSM. The prognostic value of hsTnT at baseline was compared with the conventional cTnT troponin assay and with N-terminal pro-brain natriuretic peptide concentrations. Long-term follow-up was available for 153 patients (98.1%). Highly sensitive troponin T values ranged from 0.001 to 357.2 pg/mL [median 27.2 (25th-75th percentile 9.4-69.4) pg/mL]. The hsTnT value was measured immediately before surgery and in the morning of the first postoperative day. RESULTS: The baseline hsTnT was 13 ng/L (7-26 ng/L) and 273 patients (45.7%) had baseline hsTnT above the 99th percentile/upper reference limit (URL) (14 ng/L). The median for hsTnT at first postoperative day was 235 ng/L (152-425 ng/L).

The mean age was 68.3 years in the normal hsTnT group and 69.7 years in the elevated hsTnT group. After stress testing, hsTnT concentrations for the 3 patient groups did not change from baseline to 18 min [−0.41 (−0.81, 0.01), 0.01 (−0.75, 0.79), and 0.36 (−0.42, 1.01) ng/L, respectively] or from baseline to 4 h [−0.56 (−1.82, 0.74), 0.24 (−0.60, 1.45), and 0.23 (−0.99, 1.15) ng/L] . hsTnT were available in 888 patients (438 without diabetic nephropathy, 450 with diabetic nephropathy). Of these, 104 patients had hsTnT levels below the detection limit. At baseline, hsTnT was higher in patients with diabetic ne-phropathy than in patients with normoalbuminuria (median [interquartile range]: 8.9 [4.1–17.2] vs. 3.1 [1.1–6.0 Combination of baseline hsTnT levels with the sPESI allowed a more reliable identification of patients with a favorable long-term (6-month) prognosis (Figure 3, bottom, P<0.001; and Figure 4).

We aimed to assess the relationship 2018-10-09 · The changes in hsTnT levels from baseline to 1 year were larger, but not significantly so, among those with more frequent hypoglycemia: median of 0.6 ng/l (IQR: –1.3 to +2.7 ng/l) in those without hypoglycemia, 1.0 ng/l (IQR: –1.3 to +3.3 ng/l) in those with episodes less than weekly, and 1.0 ng/l (IQR: –1.0 to +3.4 ng/l) among those with episodes greater than or equal to weekly (p = 0.075). Whereas hsTnT levels were <14 ng/L (limit of quantification) in these control subjects (3.34 ng/L, 3.96 ng/L and 5.97 ng/L), hsTnT baseline values were >14 ng/L and thus pathologically elevated in 4 patients.

single baseline mea- surement of Elecsys. Troponin T high-sensi- tive assay for diagnosis of acute myocardial infarction in emer- gency department: systematic

2019-07-09 · For pragmatic reasons, baseline data including prevalence of comorbidities such as CKD and CHF, which may influence hsTnT values, was not collected. However, the prevalence of CKD in the regional population has been previously reported to be 10.6% [ 11 ]. We performed a nested prospective biomarker study in 6308 patients, analysing hsTnT, NT-proBNP, and GDF-15 at baseline and 12 months.

Ankle brachial pressure index (ABI), N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity troponin T (hsTnT) were measured at baseline. Pulse wave velocity (PWV) and carotid intima media thickness were measured 1 year into follow-up. Data were analysed using Cox proportional hazards models.

If there is no previous hsTnT in the past 12 hours, the test will be considered a baseline hsTnT, whereas if a previous hsTnT has been measured within the past 12 hours, the test will be considered a follow-up hsTnT(see appendix B). The baseline hsTnTresult is reported In 1600 patients with suspected acute coronary syndrome (48.4% women; median age, 55 years), a single hsTnTlevel less than 6 ng/L at baseline had a negative predictive value for AMI of 99.4%. In 974 patients (77.1%) with both 0-hour and 3-hour hsTnT levels of 19 ng/L or less, the negative predictive value for 30-day ACE was 99.3% (95% CI, 99.1-99.6). The hsTnT value was measured immediately before surgery and in the morning of the first postoperative day. RESULTS: The baseline hsTnT was 13 ng/L (7-26 ng/L) and 273 patients (45.7%) had baseline hsTnT above the 99th percentile/upper reference limit (URL) (14 ng/L). The median for hsTnT at first postoperative day was 235 ng/L (152-425 ng/L).

Result > 100 ? > 6 hrs of symptoms? 2 ndhsTnT (taken at >6 hours post symptom onset AND >3 hours from 1st test) 1st or 2 Result > 14 and > 50% change ? YES YES NO NO YES NO When investigating an acute MI, order the hsTnT test.
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A rule-out strategy based on a single hsTnT at presentation and using lower cutoffs has been proposed by others.

High-sensitivity troponin T (hsTnT) is a marker of cardiovascular disease (CVD) and in type 2 diabetes also a marker of renal events, but has not been evaluated in type 1 diabetics. We therefore reviewed a type 1 diabetes cohort of 442 without and 458 with diabetic nephropathy. Baseline samples were analyzed for hsTnT levels.
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Linear regression analysis was used to identify predictors of baseline hsTnT levels and myocardial infarction. RESULTS: Elevated hsTnT was observed in 58 of the 204 patients (28.4). The mean age was 68.3 years in the normal hsTnT group and 69.7 years in the elevated hsTnT group.

The median for hsTnT at first postoperative day was 235 ng/L (152-425 ng/L). Baseline NT‐proBNP and hsTnT levels were measured in the TIMI Clinical Trials Laboratory in 14 565 patients. Among the included patients, 9143 patients (62.8%) were male, 1464 (10.1%) had a history of HF and the mean age was 63.9. Severe hypoglycemia was associated with 34% higher 1-year hsTnT levels (p < 0.0001) in unadjusted analysis, 17% higher (p = 0.006) after adjustment for baseline factors unrelated to diabetes, and 6% higher (p = 0.23) after further adjustment for the duration and severity of diabetes.

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When investigating an acute MI, order the hsTnT test. If there is no previous hsTnT in the past 12 hours, the test will be considered a baseline hsTnT, whereas if a previous hsTnT has been measured within the past 12 hours, the test will be considered a follow-up hsTnT (see appendix B). The baseline hsTnT result is reported

sensitivity troponin (hsTnT) assays, occurs commonly after noncardiac surgery.1e3 Higher mortality rates are associated with pre- and postoperative hsTnT values above the 99th centile values.4e6 An increase 25% from baseline high-sensitive cardiac troponin T (hsTnT) values was associated with a higher rate of noncardiac complications within 30 2011-03-25 · The baseline sample was taken a median of 4.0 h (interquartile range 2.0–8.6) from symptom onset. A breakdown of these results into two-hour intervals of time from symptom onset to baseline sample, shown in Figure 3 a, suggests how hsTnT is raised in patients with AMI at earlier time points than both TnT and TnI 3.