2018-09-01

Particle enrichment in two-phase microfluidic systems using acoustophoresis Anna Fornell1, Johan Nilsson1, Linus Jonsson1, Prem Kumar Periyannan Rajeswari2, Haakan N. Joensson2 and Maria Tenje1,3 1Dept. Biomedical Engineering, Lund University, Lund, Sweden E-mail: anna.fornell@bme.lth.se 2Div. Proteomics and Nanobiotechnology, Science for Life Laboratory, KTH Royal Institute of Technology,

Particle separations using flow, including pinched flow fractionation, det An acoustophoresis-based microfluidic flow-chip is presented as a novel platform to facilitate analysis of proteins and peptides loosely bound to the surface of beads or cells. The chip allows for direct removal of the background surrounding the beads or cells, followed by sequential treatment and collection of a sequence of up to five different buffer conditions. Fig. 7 Sorting of droplets in upper/lower outlet. a) No ultrasound, droplets followed the flow to the lower outlet. b) Excitation at 463 kHz generated a /2 mode, which deflected droplet paths to the upper outlet.

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Fig. 7 Sorting of droplets in upper/lower outlet. a) No ultrasound, droplets followed the flow to the lower outlet. b) Excitation at 463 kHz generated a /2 mode, which deflected droplet paths to the upper outlet. In c) and d), droplets were sorted by switching the excitation frequency between 463 kHz and 979 kHz, corresponding to the /2 and the mode, respectively. The corresponding ESI Movie ii ABSTRACT Microfluidic acoustophoresis is a nonlinear acoustic phenomenon that can induce the motion of microparticles or cells under acoustic excitations in Digital microfluidics is a field of microfluidics where electrowetting is used to control and manipulate discrete fluid droplets. This idea is inspired by digital microelectronics but instead of electric current, discrete (or digitized) droplets are used to move a certain quantity of fluid or a reactant contained within over a certain distance in a certain time. Novel Cell Sorting and Separation Market: Focus on Acoustophoresis, Buoyancy-activated, Dielectrophoresis, Magnetophoretics, Microfluidics, Optoelectronics, Photoacoustics, Traceless Affinity and Other Technologies, 2019-2030 Novel Cell Sorting - Market research report and industry analysis - 12665139 2016-02-01 · Microparticle acoustophoresis in wider silicon channels (width: 340 μm) has been investigated as well.

We demonstrate that their  Keywords.

19 Sep 2017 Their device relies on so-called “acoustofluidics,” which combines high- frequency sound waves with microfluidic technology. Essentially 

Acoustophoresis: the art of combining acoustics and microfluidics The manipulation of particles is an essential feature of Lab-on-a-chip (LOC) devices. LOC-systems provide a platform where biochemical assays can be miniaturized, integrated and automated in a simple, portable, fast and cost-efficient way. These microfluidic devices mostly use interdigital transducers (IDTs) embedded underneath the microchannels.

Droplet microfluidics has shown great potential for on-chip biological and chemical assays. Acoustophoresis is a common method to focus, enrich, and sort bioparticles in microfluidic channels. 16–23 16. A. Fornell, J. Nilsson, L. Jonsson, P. K. Periyannan Rajeswari,

The inertial microfluidics can be used for particle manipulation in a wide range of flow rates by tuning geometry and fluid6,8,9. The acoustophoresis is also a useful technique for rapid and controlled manipulation of bioparticles without affecting their viability6,10– 14. Acoustophoresis: the art of combining acoustics and microfluidics The manipulation of particles is an essential feature of Lab-on-a-chip (LOC) devices. LOC-systems provide a platform where biochemical assays can be miniaturized, integrated and automated in a simple, portable, fast and cost-efficient way. Microfluidic, Label-Free Enrichment of Prostate Cancer Cells in Blood Based on Acoustophoresis | Analytical Chemistry Circulating tumor cells (CTC) are shed in peripheral blood at advanced metastatic stages of solid cancers.

Droplet microfluidics has shown great potential for on-chip biological and chemical assays. Acoustophoresis is a common method to focus, enrich, and sort bioparticles in microfluidic channels. 16–23 16.
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In silicon microdevices, water-in-oil droplets of 200 μm size were generated for a set of unit operations including droplet fusion, focusing, sorting and medium exchange around 0.5-1 MHz acoustic frequency.

Droplet microfluidics has shown great potential for on-chip biological and chemical assays.
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acoustophoresis, microfluidics, exosomes, cell separation, miRNA, biomarkers, proteomics, acoustofluidics, cell handling, organs on a chip, diagnostics, circulating tumor cells Research We develop novel lab-on-a-chip technology for separation, enrichment and …

Fig. 7 Sorting of droplets in upper/lower outlet. a) No ultrasound, droplets followed the flow to the lower outlet. b) Excitation at 463 kHz generated a /2 mode, which deflected droplet paths to the upper outlet. In c) and d), droplets were sorted by switching the excitation frequency between 463 kHz and 979 kHz, corresponding to the /2 and the mode, respectively.