Ny data öppnar för fas 3-studie nästa år Cantargia meddelade i dagarna att bolaget ska Vi tror att den trend som CAN04 visade upp i de preliminära data som

Cantargia presenterar nya data från prekliniska studier med CAN04 i icke-småcellig lungcancer. October 20, 2016 02:30 ET | Source: Cantargia AB Cantargia

The results show synergistic/additive effects of combining CAN04 with the three different registered platinum-based therapies: cisplatin, carboplatin or oxaliplatin in tumor bearing mice. CAN04 is investigated in phase IIa clinical development for non-small cell lung cancer (NSCLC) and pancreatic cancer (PDAC). The new data was generated using immunohistochemistry in tumor samples from 15 patients. ”Vi är glada över att kunna presentera nya data på CAN04 i kombination med cellgifter på denna viktiga cancerkonferens.

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The molecular target for CAN04, IL1RAP, has been detected on the cancer cells in approximately 80 % of patients with bladder cancer. reported data from 1 patient in the Phase I/IIa CANFOUR trial showing that once-weekly IV CAN04..adverse events.

During 2019, Cantargia also reported positive preclinical data on the combination of CAN04 and platinum-based compounds. The new results presented at AACR show both parts of the IL-1 system to be upregulated in the tumor tissue in mice after treatment with the chemotherapy doublet cisplatin/gemcitabine (cis/gem) which is clinically used in the CANFOUR study.

The CAN04 strategy is to attack the IL1RAP target molecule using an effective antibody-based cancer treatment. The results from this trial, together with the data generated on CAN04 in combination with platinum-based chemotherapy, will be the basis for studies of CAN04 in combination with pembrolizumab and 1175 Views The company has announced new positive preclinical data which defines a novel additional development opportunity for Cantargias antibody CAN04. The molecular target for CAN04, IL1RAP, has been detected on the cancer cells in approximately 80 % of patients with bladder cancer. reported data from 1 patient in the Phase I/IIa CANFOUR trial showing that once-weekly IV CAN04..adverse events.

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CAN04 undersöks i en öppen fas I/IIa klinisk studie, CANFOUR, som undersöker The antibody CAN04 binds IL1RAP with high affinity and functions The results from this trial, together with the data generated on CAN04 in Prekliniska data visar att CAN04 kan öka effekten av cellgifter. CAN04 studeras i en öppen fas. I/IIa klinisk studie, CANFOUR, som undersöker While we acknowledge that Novartis's data has created negative sentiment, we believe CAN04 is clearly differentiated. Cantargia's Phase IIa CANFOUR trial Prekliniska data visar att CAN04 ökar effekten av cellgifter.

Cantargia avancerar utvecklingen av CAN04 genom framgångsrik uppskalning av produktionen Utvecklingen av antikroppen CAN04 fortskrider, och data som Our development program includes the product candidate CAN04, presented novel preclinical data on antibody cantargia kurs CAN04 at the Cantargia presents new preclinical data on CAN04 at the 2020 AACR Annual Meeting Both parts of the IL-1 system are upregulated in tumor tissue after chemotherapy CAN04, blocking the activity of both forms of IL-1, increases the efficacy of several different chemotherapy regimes STOCKHOLM, June 22, 2020 /PRNewswire/ -- Cantargia AB ("Cantargia") today presented new preclinical data giving additional knowledge around the mechanisms and thereby relevance of adding the STOCKHOLM, June 22, 2020 /PRNewswire/ -- Cantargia AB ("Cantargia") today presented new preclinical data giving additional knowledge around the mechanisms and thereby relevance of adding the Cantargia AB today announce new positive preclinical data which defines a novel additional development opportunity for Cantargias antibody CAN04. The molecular target for CAN04, IL1RAP, has been detected on the cancer cells in approximately 80 % of patients with bladder cancer. The antibody CAN04 binds IL1RAP with high affinity and functions through both Antibody-Dependent Cellular Cytotoxicity (ADCC) and blockade of IL-1 signaling. Preclinical data show that CAN04 The data show that by adding CAN04, response rates are higher than historical data using these standard first line chemotherapies alone. 4 out of 7 evaluable patients with metastatic pancreatic Detailed Description: CAN04 is a first-in-class fully humanized and ADCC enhanced monoclonal antibody, targeting the Interleukin 1 Receptor Accessory Protein (IL1RAP). The CAN04 strategy is to attack the IL1RAP target molecule using an effective antibody-based cancer treatment.
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Afucosylation of murine antibodies leads to enhanced binding to receptors present on immune cells, a stronger immune-cell mediated killing and a more pronounced antitumor effect. Cantargia AB meddelar idag nya positiva prekliniska data som innebär ytterligare en ny utvecklingsmöjlighet för Cantargias antikropp CAN04. Målmolekylen för CAN04, IL1RAP, har påvisats på cancercellerna hos cirka 80 % av patienterna med urinblåsecancer.

De visar att CAN04 kan kombineras på ett säkert sätt med cellgifter för att förstärka med Can04 jämfört med enbart cellgifter!!
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CAN04 is investigated in an open label phase I/IIa clinical trial, Preclinical data show that CAN04 increases the efficacy of chemotherapy. CAN04 is investigated in a phase I/IIa clinical trial, CANFOUR, Cantargia announce positive preclinical data on CAN04 in bladder cancer. 23 Aug 2019 - 13:00.

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CAN04 är en antikropp i fas IIa klinisk utveckling mot icke-småcellig Därigenom kommer viktiga kompletterande data erhållas vilket möjliggör

De visar att CAN04 kan kombineras på ett säkert sätt med cellgifter för att förstärka med Can04 jämfört med enbart cellgifter!! ”When combining CAN04 with cisplatin or carboplatin in this model an increased effect could be seen which was more to advance the development of CAN04 in both NSCLC and PDAC. During Q4, we expect Novartis to present data from its ongoing ph III trial utvecklas antikroppen CAN04 som är dubbelverkande, den bekämpar cancer Du ska planera, initiera och driva försök, analysera data och dra slutsatser.